Through our Research & Development (R&D) we have begun to unlock the secret powers Saffron has to offer.
Working with our partners at Aston University, we are working to examine the usage of the functional properties of Saffron in...
1. Combating neurological diseases
2. Wound dressing for burns
Currently, our work has been focused around the scientific studies exploring the use of Saffron to treat mild to moderate depression and Alzheimer’s Disease.
Here, we have highlighted the relevant scientific articles and some friendly videos in case you would like to learn about Saffron Science.
Saffron & Depression!
As an Antidepressant
“One of the most established findings regarding the benefits
of saffron is its antidepressant activity.
There are clinical trials conducted, evaluating the efficacy of saffron in mild-to-moderate depression.
The studies reported that saffron was more effective than placebo and at least equivalent to the therapeutic doses of imipramine and fluoxetine.
One of the top five most predominant diseases worldwide is depression.
Depression can affect the quality of life of someone because of the fact that it can cause a headache, difficulty in thinking, and loss of interest.”
(Siddiqui MJ, Saleh MSM, Basharuddin SNBB, et al. Saffron (Crocus sativus L.): As an Antidepressant. J Pharm Bioallied Sci. 2018;10(4):173–180. doi:10.4103/JPBS.JPBS_83_18)
2. The effects of Crocus sativus (saffron) and its constituents on nervous system: A review
“Saffron has been suggested to be effective in the treatment of a wide range of disorders including coronary artery diseases, hypertension, stomach disorders, dysmenorrhea and learning, and memory impairments.
In addition, different studies have indicated that saffron has anti-inflammatory, anti-atherosclerotic, antigenotoxic and cytotoxic activities.”
“Administration of saffron 30 mg/day (15 mg twice daily) was found to be as effective as donepezil for the treatment of mild-to-moderate AD in the subjects of 55 years and older (Akhondzadeh et al., 2010a)”
“In a randomized and double-blind clinical trial study, saffron supplementation statistically improved the mood of subjects compared to the placebo group. For six weeks, 30 mg/day of saffron was given and subjects were evaluated based on the Hamilton Depression Rating Scale (HAM-D) (Akhondzadeh et al., 2005).
Another similar study by Noorbala et al. (2005) revealed that the six-week administration of saffron extract (30 mg/day) was effective in the treatment of mild to moderate depression. These effects were similar to the effects of fluoxetine (Noorbala et al., 2005) and imipramine 100 mg/day (Akhondzadeh et al., 2004).”
(Khazdair MR, Boskabady MH, Hosseini M, Rezaee R, M Tsatsakis A. The effects of Crocus sativus (saffron) and its constituents on nervous system: A review. Avicenna J Phytomed. 2015;5(5):376–391.)
3. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial.
“In this double-blind, single-center trial and randomized trial, patients were randomly assigned to receive capsules of saffron 30 mg/day (BD) (Group 1) and capsule of fluoxetine 20 mg/day (BD) (Group 2) for a 6-week study.
Saffron at this dose was found to be effective, similar to fluoxetine in the treatment of mild to moderate depression.”
(Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, South Kargar Avenue, Tehran 13337, Iran.)
4. Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease
"A 22-week double-blind controlled trial was done to compare Crocus sativus (Saffron extract) with the cholinesterase inhibitor donepezil (Donepezil) as treatments for subjects with mild to moderate Alzheimer’s disease.
Participants in the clinical trial were randomly administered either a 30 mg/day capsule of saffron or 10 mg/day of donepezil .
After the 22-week study, it was found that saffron had a similar effect in the improvement of cognitive function in subjects with Alzheimer’s disease as donepezil (Donepezil), due to the acetylcholinesterase frequency being at a similar level .
(Adalier N, Parker H. Vitamin E, Turmeric and Saffron in Treatment of Alzheimer's Disease. Antioxidants (Basel). 2016;5(4):40. Published 2016 Oct 25. doi:10.3390/antiox5040040)